منابع مشابه
Congenital thyroid hemiagenesis with multinodular goiter
Thyroid hemiagenesis is a rare form of thyroid dysgenesis characterized by an absence of half of the thyroid gland. Developmental hemi-thyroid anomalies can result from either an abnormal descent or an agenesis of one lobe of the thyroid gland. We report a case of a 40-year-old woman with history of a longstanding gradually progressive thyroid swelling without any complication. An ultrasonograp...
متن کاملAn endoplasmic reticulum storage disease causing congenital goiter with hypothyroidism
In humans, deficient thyroglobulin (Tg, the thyroid prohormone) is an important cause of congenital hypothyroid goiter; further, homozygous mice expressing two cog/cog alleles (linked to the Tg locus) exhibit the same phenotype. Tg mutations might affect multiple different steps in thyroid hormone synthesis; however, the microscopic and biochemical phenotype tends to involve enlargement of the ...
متن کاملCongenital Goiter Presenting as a Transient Neck Swelling in a Newborn: A Case Report
Background: Goiter is not frequently seen in the neonatal period.Case report: We report the case of a full-term neonate who was born with anterior neck swelling and observed tosuffer from congenital goiter on examination. Thyroid function tests were within normal limits. Thyroid swellinggradually reduced in size during the 1st week of life. All the cases of congenital goiter t...
متن کاملUnfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism.
The unfolded protein response (UPR) is an intracellular signaling pathway that regulates the protein folding and processing capacity of the endoplasmic reticulum (ER). The UPR is induced by the pharmacological agents that perturb ER functions but is also activated upon excessive accumulation of the mutant secretory proteins that are unable to attain correct three-dimensional structure and are t...
متن کاملEndemic Goiter
ENDEMIC GOITER. The Adaptation of Man to Iodine Deficiency. By John B. Stanbury, Gordon L. Brownell, Douglas S. Riggs, Hector Perinetti, Juan Itoiz, and Enrique B. Del Castillo. Cambridge, Massachusetts, Harvard University Press, 1954. 209 pp. $4.00. This monograph reports the results obtained by the Andean Goiter Expedition, a joint project undertaken by Harvard Medical School, the University ...
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ژورنال
عنوان ژورنال: American Journal of Diseases of Children
سال: 1921
ISSN: 0096-8994
DOI: 10.1001/archpedi.1921.04120050048007